GI News is published online every month by the
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Charles Perkins Centre, and delivered to the mailboxes of our 97,000
subscribers. Our goal is to help people choose the high-quality carbs
that are digested at a rate that our bodies can comfortably accommodate
and to share the latest scientific findings on food and diet with a
particular focus on carbohydrates, dietary fibres, blood glucose and the
glycemic index.
Publisher: Professor Jennie Brand-Miller, AM, PhD, FAIFST, FNSA
Editor: Philippa Sandall
Scientific Editor/Managing Editor: Alan Barclay, PhD, APD, AN
Contact GI News: glycemic.index@gmail.com
Sydney University Glycemic Index Research Service
Manager: Fiona Atkinson, PhD, APD, AN
Contact: sugirs.manager@sydney.edu.au
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1 February 2020
GI News - February 2020
Posted by
GI Group
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5:08 am
FOOD FOR THOUGHT
SEAFOOD: GET HOOKED SUSTAINABLY
Dietitian Nicole Senior reports.
If
any food could be considered a super food, it’s seafood (fish and
shellfish). High in protein, and low in saturated fat, it’s a major
source of healthy long-chain omega-3 fats and rich in nutrients such as
iron, zinc, selenium, iodine, and vitamin D. And there is strong
evidence eating it is good for the heart. Quality observational studies
have shown approximately one to two 100-gram (3½-ounce) servings of
fatty fish a week – salmon, herring, mackerel, anchovies, or sardines –
reduce the risk of heart disease.
There is also consistent evidence that consuming fish two to
three times a week along with leafy greens and other fruit and
vegetables daily and low GI carbohydrates can reduce your risk of
developing macular degeneration, or help to slow its progression if it
has already become established.
HOW MUCH SEAFOOD?
Nutrition guidelines around the world suggest adults eat two serves of
seafood a week. A serving is 100g (3½oz) of cooked (or 115g/4oz raw),
which is around the size of your hand, or the amount in a small can.
While battered and deep‐fried fish ’n’ chips are delicious, steamed,
broiled/grilled, baked or pan‐fried fish are better options. Boost the
health benefits and serve with plenty of vegetables or salad.
WHICH FISH?
There is a huge variety of seafood to choose from but we creatures of
habit tend to stick to a limited range of our favourites that are quick
and easy to prepare and available all year round. However, globally,
overfishing is a big problem. Taking pressure off fish stocks means we
need to branch out and try different types of seafood. An added bonus is
the less popular species tend to be cheaper.
If you
want to expand your options, ask the fishmonger about what’s local and
abundant or check out the “nose to tail” movement that promotes using
all of the animal or in this case, fish. We as citizen-eaters can help
by eating “fin to fin” (i.e. the whole fish and not just our favourite
boneless, fillets) and not wasting any because throwing seafood in the
bin stinks to high heaven and just adds insult to injury (it wastes the
already significant environmental costs in producing it). If you have
the space, you can bury your seafood scraps in the yard or garden to
enrich the soil.
Look online, and you’ll find there are
a number of people and organisations already promoting lesser-known
fish with tips on how to choose and recipes to get great results. If you
want to be adventurous in the kitchen, a good place to start would be
Josh Niland’s The Whole Fish Cookbook (Hardie Grant), which is packed with ideas for cooking undervalued and less celebrated fish, and yes, the whole fish.
WHICH FISH IF YOU ARE PREGNANT?
Now is the time to be selective. Avoid raw fish (e.g. sashimi, sushi),
pre‐cooked prawns and smoked salmon due to the risk of listeria (a
bacteria that can cause problems for the unborn child if the mother
becomes infected). Fish and seafood are nutritionally important foods
during pregnancy but some species contain high levels of mercury and
some caution is required. Check your local health authority for which
species to limit or avoid, but keep in mind most are OK and seafood
provides essential nutrients during pregnancy. In general, predator fish
species at the top of the food chain accumulate higher levels of
mercury – smaller fish species are lower in mercury. Canned fish
products are not high in mercury.
WHAT ABOUT SUSTAINABILITY?
Many
people are concerned about seafood sustainability, but the twice a week
recommendation for health (around 200g total) is about the amount of
fish the EAT-Lancet Planetary Health Diet recommends (28g/day or
196g/week) to eat sustainably within natural limits. In reality most
people eat less than this now, so sustainability concerns need not stop
you from the twice a week target, provided you choose wisely.
Josh
Niland sees sustainability as a three-pronged approach. “First, you
have to be aware of the stock status of the species, Second, you have to
be aware of the practices of the fishermen who caught your fish. Was it
trawled in large nets or individually line caught? Finally, waste
minimisation.” He believes we need to give far more consideration to the
elements that traditionally would be considered as waste. Many of the
world’s most highly desired and loved dishes have been born from the
utilisation of waste. Why should fish be different?
Choosing
sustainable seafood is important to ensure an ongoing supply for future
generations. How? Look for sustainability logos when shopping for
packaged seafood, such as the MSC (Marine Stewardship Council) logo.
Check out the sustainability status of fresh fish and seafood in your
country via websites or apps, such as the SAFS (Status of Australian
Fish Stocks).
Read more:
- Is your favourite seafood sustainable?
- There aren’t plenty of fish in the sea so let’s eat all we can catch
- The Whole Fish Cookbook, Josh Niland
- EAT-Lancet Commission on Food, Planet, Diet and Health
Nicole Senior is an Accredited Nutritionist, author, consultant, cook, food enthusiast and mother who strives to make sense of nutrition science and delights in making healthy food delicious. Contact: You can follow her on Twitter, Facebook, Pinterest, Instagram or check out her website.
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5:07 am
WHAT’S NEW?
GO LOW GI – THE DIABETES BENEFITS KEEP STACKING UP
Almost
40 years ago, David Jenkins and colleagues published the first paper to
propose that the glycemic index of foods might be an important measure
of nutrition quality. “It was introduced back in 1981 to rate the
glycemic character of the carbohydrate in individual foods like bread,
breakfast cereal, rice, pasta, apples etc,” says Prof Jennie
Brand-Miller. “The purpose was to swap one carbohydrate source with
another for snacks and in your meals (e.g. replacing a high GI breakfast
cereal like corn flakes with a low one like natural muesli).”
Choosing good carbs that are low or lower GI for your meals or
snacks is now a key dietary choice if you have diabetes. Evidence based
recommendations about diet and nutrition from the world’s major diabetes
organisations advise people with diabetes to use the GI or GL to help
them manage blood glucose levels and reduce their risk of complications
including diabetic retinopathy and kidney disease.
Check
out the latest findings from two important systematic literature
reviews and meta-analyses of randomised controlled trials – considered
to be the highest level of evidence.
- For controlling HbA1c and fasting blood glucose: A systematic review and meta-analysis published in Nutrients in 2018 shows low-GI diets are more effective in controlling HbA1c and fasting blood glucose than higher GI diets and the range of other diets that are typically recommended for people with diabetes including conventional carbohydrate exchange, high fibre and standard diabetic diets.
- For reducing risk of type 2 diabetes: A systematic review and meta-analysis published in Nutrients in 2019 shows glycemic index and glycemic load are important markers of food quality and do an excellent job of predicting type 2 diabetes risk for the population as a whole.
THE GOOD CARBS? These whole foods include milk and yoghurt; fruits and berries; starchy vegetables (potatoes, sweet potatoes, sweet corn); legumes (beans, peas, lentils); nuts and seeds; and grains (oats, rice, buckwheat, quinoa etc) and the traditional staple foods we make from them including noodles, pasta and sourdough and grainy breads.
GOING LOW GI Think of it as adding a filter to your regular healthy eating pattern. First, it only applies to the carb-rich fruits, starchy vegetables, legumes and grains you like to eat. Second, it’s flexible and can be tailored to suit a range of dietary patterns from high carb to low; Mediterranean to Asian; paleo to vegetarian/vegan; gluten-free or low FODMAP. Here’s our 2-step approach to going low GI.
- Step 1: Swap it: Replace the high GI foods in your diet with low GI ones. You can find out more about how to do this HERE.
- Step 2: Don’t overload on carbs: Choosing low GI is not a free pass to pile your plate. Keep carb-rich portions moderate so the glycemic load is moderate too. What’s moderate? It’s about a quarter of your dinner plate (inner rim) or 2–3 small lower GI potatoes such as Carisma, GiLicious, Nadine or Nicola, ½ cup diced orange-fleshed sweet potato or corn kernels or baked beans and ⅓ cup cooked basmati or other lower GI rice or al dente pasta.
FIND THE GI OF YOUR FAVOURITE FOODS
Check out the Good Carbs Food Facts story in each issue. We create a complete nutrition information panel for these whole foods and traditional staples made from them along with their GI value and the GL of a typical serving. Use the search box at the top right-hand column of GI News to search for your favourite foods.
Search the International GI Database on the official website for the glycemic index based in the Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders and Charles Perkins Centre at the University of Sydney: glycemicindex.com.
Read more:
- The Effect of Dietary Glycaemic Index on Glycaemia in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies
- Dr Alan Barclay: Reduce Glycemic Load and Reduce Type 2 Diabetes Risk
- Initiative on gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and care
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5:06 am
PERSPECTIVES WITH DR ALAN BARCLAY
EATING FOR HEALTHY EYES
The risk of developing eye disease
increases as we age, potentially undermining our quality of life. The
most common eye diseases associated with ageing are:
- Age-related cataracts, a clouding of the normally clear lens of the eye, are a leading cause of vision impairment and blindness.
- Diabetic retinopathy is associated with diabetes and is a major cause of visual impairment and blindness. It develops when persistently high blood glucose levels damage the small blood vessels in the retina.
- Dry eye disease/syndrome occurs when the eyes don’t make enough tears to stay lubricated. This can make the eyes feel irritated, and in some cases, can also cause vision problems.
- Glaucoma, which may cause poor eyesight and can lead to blindness, occurs when the eye’s optic nerve is damaged due to increased pressure in the eye.
- Macular degeneration (also known as age-related macular degeneration or AMD) is a leading cause of blindness and severe vision loss. It refers to a group of degenerative diseases of the retina – in particular the macula, which is responsible for central and fine-detail vision.
The eye is particularly susceptible to oxidative damage, and oxidation and inflammation are implicated in the development of all of the common eye diseases associated with ageing. There is some evidence that dietary antioxidants and anti-inflammatories may help decrease the risk of age-related eye disease. This includes vitamin A, beta-carotene, lutein and zeaxanthin, and vitamins C and E; selenium and zinc; omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid; and omega-6 fatty acid, gamma-linolenic acid.
VITAMINS
Vitamin A is essential for maintaining your eyes’ light-sensing cells (photoreceptors). Insufficient vitamin A may lead to night blindness, dry eyes or blindness, depending on the severity of the deficiency. Liver, egg yolks, and full-cream dairy products are all good sources.
Beta-carotene, a red-orange pigment, can be converted into vitamin A in the small intestine. It’s found in relatively large amounts in fruits and vegetables like cantaloupe/rockmelon, apricots (fresh or dried), orange-fleshed sweet potatoes, kale, spinach, and carrots.
Lutein and zeaxanthin are yellow carotenoid antioxidants known as macular pigments that function as a natural sunscreen. They are concentrated in the macula, the central part of the retina, which is a layer of light-sensitive cells on the back wall of the eye. Consuming foods rich in lutein and zeaxanthin can reduce the risk of chronic eye diseases including age-related macular degeneration and cataracts. Kale, spinach, parsley, green peas, lettuce, squash, Brussels sprouts and pistachios are among the best sources. Egg yolks, broccoli, pumpkin, asparagus and sweet corn are also good sources. Carotenoids are better absorbed when eaten with fats or oils, so dress your vegetables and salads.
Vitamin C (ascorbic acid) is an antioxidant found in fruits and vegetables. There is some evidence it lowers the risk of developing cataracts. When taken in combination with other essential nutrients, it can slow the progression of age-related macular degeneration and visual acuity loss. Many fruits and vegetables are rich in vitamin C including berries, broccoli, Brussels sprouts, cabbage, cantaloupe/rockmelon, cauliflower, capsicum/bell peppers, citrus fruits, guavas and tomatoes.
Vitamin E is a group of fat-soluble antioxidants that protect fatty acids from harmful oxidation and thus protect cells in the eyes from unstable molecules called free radicals, which break down healthy tissue. Almonds, peanuts, sunflower seeds, and vegetable oils like safflower oil and wheat-germ oil are some of the best dietary sources of vitamin E.
MINERALS
Selenium is a powerful antioxidant. When combined with carotenoids and vitamins C and E, it can help reduce the risk of advanced age-related macular degeneration. Foods rich in selenium include seafood (shrimps/prawns, crab, salmon, halibut), poultry and eggs, Brazil nuts, enriched noodles, and brown rice (depending where it is grown). Zinc is a part of many essential enzymes. It plays a vital role in bringing vitamin A from the liver to the retina to produce melanin, a protective pigment in the eyes.
Zinc is highly concentrated in the eye, mostly in the retina and choroid, the vascular tissue layer lying under the retina. It also appears to be involved in the formation of visual pigments in the retina. For this reason, zinc deficiency may lead to night blindness. Good sources include meat, seafood (fish and shellfish), poultry, dairy milk and yoghurt and peanuts.
FATS
Omega-3 fatty acids (eicosapentaenoic acid or EPA and docosahexaenoic acid or DHA) are important for eye health. DHA is found in high amounts in the retina, where it may help maintain eye function, and help decrease oxidative stress and inflammation. It’s also important for brain and eye development during infancy. DHA deficiency may impair vision, especially in children. The best dietary sources are oily seafood like salmon, trout, herring, sardines, crab and shrimps/prawns.
Gamma-linolenic acid (GLA) is an omega-6 fatty acid that appears to have anti-inflammatory properties. Sources include evening primrose oil and hemp seed oil.
CARBOHYDRATES
Carbohydrates (sugars and starches) have the greatest impact on our blood glucose levels. Consuming too much carbohydrate overall or too many high GI carbohydrates can lead to persistently high blood glucose levels and increase your risk of developing diabetic retinopathy, macular oedema, cataracts and glaucoma.
Talk to an Accredited/Registered dietitian to find out how much carbohydrate is right for you, and enjoy the low or lower GI varieties including quality wholegrains (e.g., grainy bread, al dente wholewheat pasta), legumes (beans, lentils and chickpeas), fruit and veggies (apples, pears, corn, peas, sweet potato, butternut pumpkin), dairy milk and yoghurt.
PUTTING IT ALL ON YOUR PLATE:
To help maintain optimal eye health, eat more fruits and vegetables, enjoy moderate amounts of quality meat, seafood and/or poultry and make most of low or lower GI carbohydrates.
Read more:

Alan Barclay, PhD is a consultant dietitian and chef (Cert III). He worked for Diabetes Australia (NSW) from 1998–2014 . He is author/co-author of more than 30 scientific publications, and author/co-author of The good Carbs Cookbook (Murdoch Books), Reversing Diabetes (Murdoch Books), The Low GI Diet: Managing Type 2 Diabetes (Hachette Australia) and The Ultimate Guide to Sugars and Sweeteners (The Experiment, New York).
Contact: You can follow him on Twitter or check out his website.
Posted by
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5:05 am
DIABETES CARE
DIABETIC EYE DISEASES
Ophthalmologist Dr Shanel Sharma
explains why it’s vital to be vigilant if you have diabetes and why the
eye is vulnerable to damage from the complications of diabetes.
Diabetes
is the most common cause of blindness for people between 20 and 65 and
diabetic eye diseases can affect anyone with diabetes whether type 1 or
type 2. Chronically high blood glucose levels over time damage blood
vessels throughout the body. Our small blood vessels are the most
vulnerable and are affected first. These include the small blood vessels
supplying our eyes, kidneys and our peripheral limbs (toes). People
with chronically elevated blood glucose levels have substantially more,
and more severe, retinopathy than those with lower blood glucose levels.
What
happens in the eye is that the blood vessels become damaged and develop
micro-aneurysms, start to bleed causing haemorrhages and stop carrying
blood, resulting in retinal ischaemia. Ischaemic retina causes the
release of a protein (VEGF – vascular endothelial growth factor),
resulting in the development of sick and abnormal blood vessels, which
can bleed or cause tractional retinal detachment and loss of vision. The
other major way people lose sight is from diabetic macular oedema, from
leaking of blood product into the macular. The macular is the part of
the eye that allows one to read, look at people’s faces, or do any fine
detailed work.
As there is usually a 10–15-year delay in chronically high BGLs
and appearance of diabetic eye diseases, it is important to control BGLs
well from the start. Although the damage to the eye is irreversible,
early detection and treatment can reduce the risk of blindness by up to
approximately 95%.
If you are diagnosed with diabetic
retinopathy, don’t despair. Good blood glucose control can reduce its
progression. People with diabetes who follow healthy eating principles
can reduce their HbA1c levels by 1 to 2 percentage points. On a low GI
diet, they can reduce can HbA1c levels by another 0.5 percentage points.
While this may not sound significant, a decrease of just 1 percentage
point in HbA1c levels will decrease the common complications of diabetes
by 19% to 43%. Talk to your doctor or diabetes educator.
Reducing
blood pressure helps too. The UK Prospective Diabetes Study showed a
reduction of 10mmHg systolic and 5mmHg diastolic reduces the rate of
retinopathy by 30%.
As diabetic eye diseases most
commonly have no symptoms, it is essential to ensure that you are being
screened regularly by your GP, optometrist or your ophthalmologist.
Symptoms that are associated with diabetic eye diseases can include
intermittent blurred vision, difficulty with focusing, loss of contrast,
double vision or distortion to your vision. Additionally, diabetes is
an independent risk factor for developing other eye diseases such as
cataracts and glaucoma.
Protecting your eyesight is one of the most important things you can do to ensure quality and enjoyment of life.
Read more:
- Preventing Diabetic Retinopathy Progression
- Diabetic Retinopathy and Systemic Factors
- Blood pressure control for diabetic retinopathy
- Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus (UK Prospective Diabetes Study)
- Dietary hyperglycemia, glycemic index and metabolic retinal diseases
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5:04 am
YOUR GI SHOPPING GUIDE
MILK
We aren’t buying into the milk/fake milk debate. We know
people have a whole range of reasons (health, cultural, religious,
environmental, ethical) for choosing plant milks rather than dairy. We
do recommend you check the ingredient list for plant milks and choose
one with added calcium and B12.
For people with diabetes – Many people count grams of
carbohydrate or use 15g Carbohydrate Exchange or 10g Portions to help
match their insulin or blood glucose lowering medication to their
requirements. We have included both. A 15g Exchange includes food with
12–18g carbohydrate and a 10g Portion 7.6–12.5g of carbohydrate.
Dairy
Cow’s milk, full fat (4%)
GI 30 (27–34)
Serving: 1 cup (250ml/9 fl oz)
Cow’s milk, reduced fat (1–2%)
GI 29 (20–30)
Serving: 1 cup (250ml/9 fl oz)
Cow’s milk, low/no fat, skim (less than 1%)
GI 29 (20–30)
Serving: 1 cup (250ml/9 fl oz)
Plant milks
Almond milk, unsweetened
GI 25
Serving: 1 cup (250ml/9 fl oz)
Oat milk
GI 69
Serving: 1 cup (250ml/9 fl oz)
Rice milk, regular
GI 79
Serving: 1 cup (250ml/9 fl oz)
Rice milk, low fat
GI 92
Serving: 1 cup (250ml/9 fl oz)
Soy milk, regular, added calcium,
GI 30 (24–37)
Serving: 1 cup (250ml/9 fl oz)
Soy milk, reduced/low fat, added calcium,
GI 36 (34–38)
Serving: 1 cup (250ml/9 fl oz)
Read more:
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5:03 am
GOOD CARBS FOOD FACTS
BROCCOLI
Broccoli is part of the brassica family of
vegetables (also known as cruciferous vegetables) that includes cabbage
and Brussels sprouts. It has been around since Roman times and still
popular in Italy; the name comes from the Italian word broccoli meaning
the flowering crest of a cabbage. We eat the large flowering head of the
plant. Broccolini is a newer incarnation with long slender stems and
smaller heads, and also known as sprouting broccoli – they are
nutritionally the same. They all contain cancer-fighting phytochemicals
including sulforaphane. Broccoli is also a good source of the B vitamin
folate for a healthy heart, vitamin C for immunity and fibre for
digestive health.
To retain its nutritional goodness and “fight-o-chemical” power,
cook broccoli as lightly as possible – do not boil. As with all
vegetables, broccoli can be lightly steamed or microwaved and dressed
with a little extra virgin olive oil and perhaps lemon juice, pepper,
chilli, or herbs of your choice. For an Asian direction, try soy, honey
and sesame seeds. Take care not to overcook and leave some crispness and
the rich green colour. To ensure the stems cook through before the
florets go mushy, cut a cross into the base of the stem with a small
sharp knife to quicken cooking. For added delight, sprinkle over
slivered almonds (or any nut really) that have been gently toasted.
Source: AusFoods, 2019
Posted by
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5:02 am
THE GOOD CARBS KITCHEN
BAKED WHOLE SNAPPER WITH MOROCCAN SPICE PASTE
0:15 Prep (+ 30 marinating) • 0:25 Cook • 4 Servings • Main Meal • Easy Entertaining
INGREDIENTS
½ cup firmly packed coriander (cilantro) leaves + extra to garnish
½ cup firmly packed mint leaves + extra to garnish
1 long red chilli seeded and finely chopped
1 garlic clove crushed
1 teaspoon finely grated ginger
1 teaspoon ground cumin
1 tablespoon lemon juice
2 teaspoons olive oil
1 whole snapper (1kg/2lb 4oz), scaled and gutted
1 lemon thinly sliced
METHOD
Finely
chop the herbs, chilli, garlic, ginger and cumin in a food processor.
Add the lemon juice, olive oil and 1–2 tablespoons of water or enough to
make a smooth paste. Process until smooth.
Cut three
deep diagonal slashes through the skin and down to the bone on each side
of the snapper. Place in a large non-metallic dish and fill the cavity
with the lemon slices. Spread the spice paste over the fish and turn to
coat well. Cover and refrigerate for 30 minutes.
Preheat the oven to 220°C (425°F).
Place
the fish on a large paper-lined baked tray and bake for 20–25 minutes
until the thickest part flakes easily with a fork. Serve garnished with
extra coriander and mint leaves.
Tip: You can replace the snapper with 2 x 500g baby snappers. The cooking time will decrease to 15-20 minutes.
NUTRITION
Per serve
1185 kJ/285 calories; 52g protein; 7g fat (includes 1.5g saturated fat;
saturated : unsaturated fat ratio 0.3); 2g available carbs (includes 1g
sugars and 1g starch); 2.2g fibre; 219mg sodium; 1258mg potassium;
sodium : potassium ratio 0.2
RECIPE
Chrissy Freer, Book (The Anti-inflammatory Cookbook, Murdoch Books)
SALT-BAKED SNAPPER
0:20 Prep • 0:40 Cook • 4 Servings • Entertaining
INGREDIENTS
2 whole snapper, about 350g (12oz) each
1 lemon, sliced
1 bunch fresh coriander (cilantro), roots, stems and leaves, roughly chopped
1.5kg coarse sea salt
2 egg whites, beaten
2 stalks lemongrass, roughly chopped
METHOD
Preheat oven to 200°C (400°F).
Clean the snapper and put lemon slices and 1 tablespoon of the chopped coriander in the cavity and season.
Combine the salt, egg whites, lemongrass and remaining chopped coriander in a large bowl.
Spread
a layer of the salt mixture in a baking dish and top with snapper. Then
completely cover fish with remaining salt mixture. You don’t want to be
able to see any fish at all.
Bake in hot oven for 40
minutes. The salt mixture will turn to a hard crust that you can crack
with the back of a knife – this is fun to do at the table for guests.
Then take out the steaming whole fish, brushing off any excess salt.
NUTRITION
Per serve
785kJ/190 calories; 38g protein; 3g fat (includes 1g saturated fat;
saturated : unsaturated fat ratio 0.5); 1g available carbs (includes
0.8g sugars and 0.2g starch); 1g fibre; 3027mg sodium; 887mg potassium;
sodium : potassium ratio 3.4
RECIPE
Ian Hemphill with recipes by Kate Hemphill, Spice Notes and Recipes.
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5:01 am
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Nutritional analysis To analyse Australian foods, beverages, processed products and recipes, we use FoodWorks which contains the AusNut and Nuttab databases. If necessary, this is supplemented with data from www.calorieking.com.au or http://ndb.nal.usda.gov/ndb/search.
Disclaimer GI News endeavours to check the veracity of news stories cited in this free e-newsletter by referring to the primary source, but cannot be held responsible for inaccuracies in the articles so published. GI News provides links to other World Wide Web sites as a convenience to users, but cannot be held responsible for the content or availability of these sites. All recipes that are included within GI News have been analysed however they have not been tested for their glycemic index properties by an accredited laboratory according to the ISO standards.
© ®™ The University of Sydney, Australia
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5:00 am
1 January 2020
GI News - January 2020
GI News is published online every month by the
University of Sydney, School of Life and Environmental Sciences and the
Charles Perkins Centre, and delivered to the mailboxes of our 97,000
subscribers. Our goal is to help people choose the high-quality carbs
that are digested at a rate that our bodies can comfortably accommodate
and to share the latest scientific findings on food and diet with a
particular focus on carbohydrates, dietary fibres, blood glucose and the
glycemic index.
Publisher: Professor Jennie Brand-Miller, AM, PhD, FAIFST, FNSA
Editor: Philippa Sandall
Scientific Editor/Managing Editor: Alan Barclay, PhD, APD, AN
Contact GI News: glycemic.index@gmail.com
Sydney University Glycemic Index Research Service
Manager: Fiona Atkinson, PhD, APD, AN
Contact: sugirs.manager@sydney.edu.au
Like us on
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6:07 am
FOOD FOR THOUGHT
MEATY MATTERS
Dietitian
Nicole Senior ponders finding health in the happy medium
Eating meat kick-started the evolution of modern big-brained humans. But
we can actually live long and healthy lives without eating it, and many
millions do. However, it’s a highly nutritious food that provides us
with essential nutrients more difficult to obtain from plant foods.

Source: Reversing Diabetes (Murdoch Books)
Red
meat, for example, is rich in iron necessary for healthy blood, zinc
for immunity and vitamin B12 for healthy DNA and cell division. Sure,
there are vegetarians who thrive on a meatless diet, but there are also
those who don’t and take nutrient supplements to make up the shortfall.
In some poor countries, where people cannot afford to eat meat,
iron-deficiency anaemia is one of the most common childhood diseases.
But meat poses ethical questions around the environment – red meat has
the highest environmental footprint – and animal welfare.
While
it’s true livestock contribute to environmental problems, the
environmental argument against meat has been infused with emotion and
ideology as to whether we should eat meat at all. Veganism is rising,
with the extremists in the movement taking a militant approach going so
far as trespassing on farms and causing damage.
The
picture has also been muddied by the rampantly excessive consumption of
meat in some rich countries and the environmentally damaging effects of
factory farming, the vast scale of commercialised livestock production
where animals become a unit in a production line, and the scandals in
Australia over the cruel export and slaughter methods of live cattle and
sheep, and more recently what happens to race horses that have passed
their use-by date (in our book). For many people the way we treat farm
animals is no longer acceptable and higher moral standards are being
demanded.
In a way, meat offers nutritional insurance
for reckless eating and incompetent cooking whereas plant-based eating
requires a new diligence both for nutritional balance and enjoyment. The
degree of difficulty of a meatless diet is much higher than an
omnivorous diet. Maybe rather than blindly following all the vegan
marketing hype (not all vegan products are healthy), we just need to be
more mindful of our diet generally? For example, reducing the amount of
nutrient-poor, highly processed foods we eat, learning to grow and cook
our own food, only buying what we can eat, and not throwing food in the
bin (which wastes the resources that went in to producing it and
produces greenhouse gases in landfill).
The question of
how much meat we can get away with eating and still look after our
health and the environment is hotly debated and depends on a myriad of
factors including: location/region, climate, production method, land and
water use, feed type, animal genetics, waste management, supply chain
efficiency, transport and wastage.
The EAT-Lancet
Commission on Food, Planet, Diet and Health report published in February
2019 took a global approach that aimed to incorporate nutritional needs
and environmental limits needs with a Planetary Health Diet. It is a
plant-based diet with 14g a day of beef/lamb/pork (98g/week) with a
range of 0–28g/day, 29g poultry per day (203g/week), 28g of fish per day
(196g/week) and 13g of egg per day (about 2 eggs/week).
This report has drawn both congratulations and criticism in equal
measure. The harshest criticism has been directed at the very small
amounts of meat, which are less than previously proposed for
environmental sustainability and less than currently recommended in
dietary guidelines. We shall wait to see how the rest of the world takes
on their recommendations.
While high intensity factory
farming such as feed lot cattle is seen as unacceptable to most on both
environmental and ethical grounds, the agricultural story around meat
production isn’t all bad. In Australia, for example, most cattle and
sheep are grass-fed on marginal land unsuitable for crops. Integrated
farming is a better and more sustainable way forward and this approach
involves mixing animal and plants on the same farm to allow for maximum
output through nutrient cycling and minimal pollution.
It
is unrealistic to think we will all stop eating meat to save the
environment or to “be kind” to animals, however, we can produce meat in a
much more sustainable and ethical way, and we can eat less meat to
minimise our environmental impact. There’s no need to banish meat from
your dinner plate – just cut back so it’s a tasty side show rather than
the main event. We as citizen-eaters can help by eating animals
“nose-to-tail” (not just our favourite bits) and not wasting any because
throwing animal foods in the bin just adds insult to injury (it wastes
the already significant environmental costs in producing it).
Australian
ex-food-critic-turned-farmer, TV presenter and author Matthew Evans
says we will need to pay more for meat that meets our higher moral
expectations, “The simplest way to better impact the animals, the land,
the farmer, is to perhaps eat meat less often, but spend more on it.”
And remember eating less red meat is easy because there is (sustainably
sourced) fish, chicken and pork with smaller environmental footprints as
well as good plant sources of protein that we should be eating more of.
This dietary strategy when taken on by the population will send a
message to producers that they can use less intensive, kinder and more
sustainable methods to produce animal foods, and can ramp up sustainable
plant food production to meet demand.
My takeout
message is this – meat is nutritionally important, but we in rich
countries should eat less; and only our fair share. We need to focus on
farming animals (and crops) more sustainably and with minimal
environmental impact.
Avowed carnivores and vegans are
dietary extremes while health is so often found in the happy medium. If
we ate according to health guidelines, both our own health and the
health of the planet and all the people living on it could be improved!
Read More:
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WHAT’S NEW?
A RED MEAT ISSUE FLAMES UP
Five – yes, five – papers in the Annals of Internal Medicine
published in October 2019 whipped up a flaming hot controversy about
nutrition guidance broadly and red meat specifically reports
ConscienHealth’s Ted Kyle. The bottom line from all these papers? Maybe
we need to admit that the evidence for harm to health from red meat is
not so hard and fast as some people like to think.
Using GRADE criteria, the certainty about the effects of red meat
on health is low. Thus, recommendations to eat less red meat for better
health are weak. In other words, there are indeed different and valid
ways to look at the issue of red meat in the diet.
Harvard’s
Frank Hu doesn’t like applying GRADE standards to nutrition advice.
“It’s really problematic and inappropriate to use GRADE to evaluate
nutrition studies,” he says. One big problem he has with the GRADE
system is that it takes randomized, controlled studies to be the gold
standard of evidence. Observational data provides weaker evidence. Such
thinking is OK for evaluating drugs. But he wrote in 2015 that the
standard should be different for nutritional epidemiology: “Some
researchers consider RCTs as the be-all and end-all of causal inference.
This sentiment may be appropriate in the pharmaceutical industry, but
the drug trial paradigm cannot be readily translated for use in the
nutritional sciences.”
However, it’s worth saying that
standards for scientific rigor were not invented by the pharmaceutical
industry. The lead on one of these five papers, Bradley Johnston,
explains:
“Regarding the reaction among some in the nutrition research community …
we are sympathetic to the discomfort of acknowledging the low-quality
evidence in one’s field. It seems to us, however, that pretending that
the rules of evidence differ across fields because the feasibility of
definitive studies is not possible in one’s particular field is a poor
solution to the problem. We believe it is important to apply common
standards for assessing the certainty of evidence across health-care
fields.”
So, what are we to think about red meat? The
evidence to say that we’re eating more red meat than we should for our
own health is weak. However, we do have other reasons to believe that
eating less red meat would be a good thing. Red meat is pretty hard on
this planet we share. A little red meat probably won’t kill you. But too
much of it might indirectly contribute to killing lots of people
through climate change.
Regardless of those facts,
opinions and feelings will drive behaviour. Some people are really
attached to the red meat in their diets. Others have strong passions for
avoiding it.
It’s not easy to be objective about
nutrition, but it’s worth a try. Dennis Bier explained this to the New
York Times: “The rules of scientific proof are the same for physics as
for nutrition.”
Read more:
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PRODUCT REVIEW
4 RED MEATS
Nutritious
red meats are valuable for their protein, iron, zinc and vitamin B12.
In Product Review, we check out how four of these meats provide the key
nutrients per serving so you can compare farmed animals with game. We
follow the Australian Dietary Guidelines for servings – a serving of red meat is 65g cooked meat or 100g (3½oz) raw meat.
Fillet steak, lean, raw
Serving: 100g/3½oz
570kJ/
136 calories; 22 g protein; 5g fat (includes 2g saturated fat;
saturated : unsaturated fat ratio 0.7); 57mg sodium; 380mg potassium;
sodium : potassium ratio 0.2; 2.2mg iron; 3.8mg zinc; 1.9ug vitamin B12.
Lamb tenderloin (fillet), lean, raw
Serving: 100g/3½oz
485kJ/
116 calories; 20g protein; 4g fat (includes 1.5g saturated fat,
saturated : unsaturated fat ratio 0.6); 70mg sodium; 370mg potassium;
sodium : potassium ratio 0.2; 2.1mg iron; 2.9mg zinc; 1.3ug vitamin B12.
Venison, lean, raw
Serving: 100g/3½oz
415kJ/
100 calories; 22g protein; 1.1g fat (includes 0.5g saturated fat,
saturated : unsaturated fat ratio 0.8); 58mg sodium; 380mg potassium;
sodium : potassium ratio 0.2; 3.1mg iron; 4.4mg zinc; 1.6ug vitamin B12.
Kangaroo, lean, raw
Serving: 100g/3½oz
400kJ/
95 calories; 21g protein; 1g fat (includes 0.3g saturated, saturated :
unsaturated fat ratio 0.4); 40mg sodium; 350mg potassium; sodium :
potassium ratio 0.1; 3.4mg iron; 2.3mg zinc; 1.9ug vitamin B12.
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PERSPECTIVES WITH DR ALAN BARCLAY
Kidneys, kidney disease and protein
Most
people have two bean-shaped kidneys, each about the size of a clenched
fist, in the rear left and right sides of their torso, just below their
ribs. They have many essential functions (e.g., regulating blood
pressure, producing hormones and activating vitamin D), but most
importantly they filter our blood and remove excess body fluids and
wastes for elimination in the urine. They are able to balance out body
fluid, electrolyte (salts) and acid (pH) levels so that all of our
organs function optimally, despite our consumption of a variety of
fluids from foods and beverages, and fluid losses from physical activity
and sweating. Here’s how they do it.
NORMAL KIDNEY FUNCTION
Blood flows from the aorta
(the main blood vessel from the heart) into the kidneys via the renal
artery. Within the kidney, the parts that filter the blood are called
nephrons. Within each nephron is a glomerulus, a bulb-like capsule which
contains tiny blood vessels that look a bit like a loosely wound ball
of wool.
When the kidney is functioning normally, these
tiny blood vessels have a large number of fine holes. They work a bit
like sieves, allowing water, some salts (e.g., sodium, potassium,
calcium, phosphorus) and waste products to pass through, but they are
too small to allow red and white blood cells, and most blood proteins,
to leak out. The exact composition of the filtered fluids (filtrate)
depends on the body’s requirements for essential minerals like sodium
and potassium, the acid-base balance (pH), and concentration of wastes
from general metabolism.
Eventually, the filtrate from
each nephron flows together and enters collecting ducts within the
kidney, where the concentration of the final urine product is
determined. The urine then travels through the ureters to the urinary
bladder for temporary storage before voluntary urination.
Kidney
function is evaluated based on the glomerular filtration rate (the rate
at which the kidneys form filtrate) and the amount of the protein
albumin lost in the urine. In health, glomerular filtration rates are
greater than 90mL/minute, and there is essentially no albumin in the
urine.
KIDNEY DISEASES
Nephrotic syndrome
occurs when the glomeruli are damaged, increasing the size of the
filtration holes, and therefore decreasing their ability to prevent
proteins (e.g., albumin, lipoproteins, clotting factors and
immunoglobulins) from escaping into the urine. The loss of these
proteins can lead to serious health problems including oedema, high
cholesterol levels, blood clotting and immune issues. Nephrotic syndrome
can be caused by infections, immune disorders, chemical damage (from
medications or illicit drugs), or poorly managed diabetes.
Chronic kidney disease
is characterised by gradual, irreversible deterioration of the
nephrons. Because we have a lot of nephrons, chronic kidney disease
develops over many years without causing any symptoms. People are
therefore often diagnosed late in the course of the illness, after most
kidney function has been lost. Like the nephrotic syndrome, damage to
the blood vessels in the nephrons leads to excessive loss of proteins in
the urine, which can lead to serious health problems including oedema,
high cholesterol, blood clotting and immune issues. Additionally, the
nephrons lose their ability to maintain electrolyte (e.g., sodium and
potassium) levels, acid-base balance (e.g., uric acid and phosphorus
levels) and uraemia (the level of urea – the waste product of protein
metabolism – in the blood). The more common causes of chronic kidney
disease include diabetes and hypertension (chronically high blood
pressure).
PROTEIN AND KIDNEY FUNCTION
The
Recommended Dietary Intake (RDI) of protein for women is 0.75 g per kg
body weight, and for men it is 0.84g per kg. High protein diets provide
more than 1.2g per kg body weight and lower protein diets less than 0.6 g
per kg body weight.
Unlike carbohydrate which is
stored as glycogen in our muscles and liver, and fat which is stored as
triglycerides in our fat cells, we have a limited capacity to store
protein. If we eat more protein than our body’s require, some of it can
be converted to glucose in the process of gluconeogenesis (see July 2019
edition of GI News). The metabolic process of converting proteins (or
more specifically amino acids – the building blocks of proteins) to
glucose leads to the production of ammonia, which in turn is converted
to urea and excreted in the urine.
HIGH PROTEIN DIETS AND KIDNEY FUNCTION
High
protein diets increase glomerular filtration rates, which increases the
pressure within the glomerulus and may cause damage in susceptible
people. High protein diets also increase urea production. On the other
hand, lower protein diets decrease the pressure within the glomerulus
and produce less urea.
The highest quality evidence
available to date suggests that high protein diets do not have a
negative effect on the glomerulus in people with healthy kidneys as the
glomerulus is able to cope with the increased pressure and higher urea
content.
However, in people with nephropathy/chronic
kidney disease, the increased glomerular pressure caused by a high
protein diet may lead to increased protein (e.g., albumin) loss in the
urine and consequently increase the rate of progression of kidney
disease. Therefore, a lower protein diet of 0.6–0.8 per kg body weight
is generally recommended to people with existing nephropathy/chronic
kidney disease. The problem is, chronic kidney disease develops over
many years without causing any symptoms, so some high-risk people (e.g.,
people with diabetes) may have the condition but not know it.
Finally,
for people with nephropathy/chronic kidney disease, approximately half
of the proteins should come from plant sources (e.g., beans, lentils,
chickpeas, etc...), as there is some evidence that they place less
stress on the kidneys than animal sources.
Read more:
- PROTEIN QandA: OUR EXPERTS ANSWER YOUR QUESTIONS
- Nutrient Reference Values: Protein
- High-protein diet is bad for kidney health: unleashing the taboo
- Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis.
- Efficacy of low-protein diet in diabetic nephropathy: a meta-analysis of randomized controlled trials
- Effect of whole soy and purified isoflavone daidzein on renal function--a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension.

Alan Barclay, PhD is a consultant dietitian and chef (Cert III). He worked for Diabetes Australia (NSW) from 1998–2014 . He is author/co-author of more than 30 scientific publications, and author/co-author of The good Carbs Cookbook (Murdoch Books), Reversing Diabetes (Murdoch Books), The Low GI Diet: Managing Type 2 Diabetes (Hachette Australia) and The Ultimate Guide to Sugars and Sweeteners (The Experiment, New York).
Contact: You can follow him on Twitter or check out his website.
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6:03 am
GOOD CARBS FOOD FACTS
BULGUR
Making
wheat into bulgur (also spelled bulgar, bulghur, burghul and bourghul)
has been an integral part of Middle Eastern cuisine for thousands of
years. These days, you can still see villagers preparing it the
traditional way: boiling the wheat in huge pots, spreading the cooked
berries or groats over flat roof tops to dry, then cracking the hardened
kernels into coarse pieces and sieving them into different sizes. Don’t
confuse it with cracked wheat, which is simply that, and can take up to
an hour to cook.
This versatile, nutty-tasting, wholegrain is available in
supermarkets, natural/organic health food stores and Middle Eastern
produce stores. If you are lucky, you’ll have a choice of grades – fine
(#1), medium (#2), coarse (#3), and very coarse (#4). You can make
pilafs with medium, coarse, and very coarse bulgur. Tabbouleh and kibbe
are best made with fine bulgur. As it’s been parboiled, it needs little
cooking and, in most cases, nothing more than a good soak in hot water.
Check out the manufacturer’s instructions.
Sources: AusFoods, 2019 and The Good Carbs Cookbook (Murdoch Books)
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6:02 am
THE GOOD CARBS KITCHEN
LAMB, FETTA AND BULGUR MEATBALLS
0:25 Prep • 0:45 Cook • 6 Servings • Family fare
INGREDIENTS
500g (1lb 2oz) lean minced (ground) beef
1 large onion, finely chopped
⅔ cup (90g/3oz) crumbled fetta
2 tablespoons chopped mint
1 teaspoon ground cinnamon
1 cup (175g/6oz) fine bulgur
2 garlic cloves, crushed
salt flakes and freshly ground pepper
¼ cup olive oil
Extra 3 large onions, thinly sliced
400g (14oz) can chopped tomatoes
1 cup water
METHOD
Put
the mince, chopped onion, fetta, mint, cinnamon, bulgur, and half the
garlic in a bowl with salt and pepper to taste. Clump the mixture
together with your hands to mix well and then cover and set aside for 1
hour. Scoop the mixture and shape into small rounds about the size of
golf balls.
Heat the olive oil in a deep non-stick pan
and then add the sliced onion and cook for about 7 minutes or until the
onions are soft but not coloured. Stir in the remaining garlic and cook
for a further 1 minute. Add the tomatoes including the juice, with the
water and salt and pepper to taste. Bring the mixture to a gentle simmer
and then place the meatballs evenly on top. Pour in enough water to
come about two-thirds of the way up the contents of the pan. Cover the
pan, reduce the heat and gently simmer for about 35 minutes or until the
meatballs are tender and cooked.
NUTRITION
Per serve
1650kJ/ 395 calories; 26g protein; 21g fat (includes 7g saturated fat;
saturated : unsaturated fat ratio 0.5); 23.5g available carbs (includes
5g sugars and 18.5g starch); 6g fibre; 295mg sodium; 610mg potassium;
sodium : potassium ratio 0.5
RECIPE
The Good Carbs Cookbook, Murdoch Books.

ROSEMARY LAMB AND VEGETABLE KEBABS WITH LEMON CRACKED WHEAT
0:30 (+ 2 hours marinating and 15 minutes cooling) Prep • 0:30 Cook • 4 Servings • Family fare • Barbecue
INGREDIENTS
12 rosemary stems
1½ tablespoons olive oil
2 garlic cloves, crushed
2 tablespoons lemon juice
½ teaspoon cracked black pepper
500g (1lb2oz) lean lamb, cut into 3cm (1¼in) cubes
250g (9oz) small button mushrooms
1 large yellow capsicum (pepper), cut into 3cm (1¼in) pieces
1 large red onion, cut into wedges
3 small zucchini (courgettes), thickly sliced
250g (9oz) cherry tomatoes
lemon wedges, to serve
Lemon cracked wheat
1 cup cracked wheat
2 tablespoons lemon juice
2 teaspoons grated lemon zest
2 spring onions (scallions) finely chopped
1 large handful parsley leaves, finely chopped
METHOD
Remove
three-quarters of the leaves from the base of each rosemary stem. (If
rosemary stems are unavailable, wooden or metal skewers can be used.
Soak wooden skewers in water for 30 minutes before use to prevent them
from burning during cooking.)
Finely chop one-third of
the leaves, discarding the remaining leaves, and set the stems aside.
Place the chopped rosemary, oil, garlic, lemon juice and pepper in a
glass bowl and mix to combine. Add the lamb and stir to coat, then cover
and refrigerate for 2 hours.
Meanwhile, to make the
lemon cracked wheat, bring 1¼ cups water to the boil in a saucepan. Add
the cracked wheat, reduce the heat and simmer for 15 minutes or until
the liquid has been absorbed. Fluff the cracked wheat with a fork, then
transfer to a bowl to cool for 15 minutes. Fold in the lemon juice,
lemon zest, spring onions and parsley. Cover and refrigerate until
needed.
Preheat a chargrill pan or barbecue plate to
medium. Thread the lamb, mushrooms, capsicum, onion, zucchini and
tomatoes onto the rosemary stems. Cook the kebabs, turning occasionally,
for 8-10 minutes or until done to your liking. Serve the kebabs with
the lemon cracked wheat and lemon wedges.
NUTRITION
Per serve 2070kJ/
395 calories; 37g protein; 16g fat (includes 4g saturated fat;
saturated : unsaturated fat ratio 0.33); 43g available carbs (includes
7g sugars and 36g starch); 13g fibre; 100mg sodium; 1280mg potassium;
sodium : potassium ratio 0.08
RECIPE
Reversing Diabetes, Murdoch Books.
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6:01 am
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Nutritional analysis To analyse Australian foods, beverages, processed products and recipes, we use FoodWorks which contains the AusNut and Nuttab databases. If necessary, this is supplemented with data from www.calorieking.com.au or http://ndb.nal.usda.gov/ndb/search.
Disclaimer GI News endeavours to check the veracity of news stories cited in this free e-newsletter by referring to the primary source, but cannot be held responsible for inaccuracies in the articles so published. GI News provides links to other World Wide Web sites as a convenience to users, but cannot be held responsible for the content or availability of these sites. All recipes that are included within GI News have been analysed however they have not been tested for their glycemic index properties by an accredited laboratory according to the ISO standards.
© ®™ The University of Sydney, Australia
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6:00 am
1 December 2019
GI News - December 2019
GI News is published online every month by the
University of Sydney, School of Life and Environmental Sciences and the
Charles Perkins Centre, and delivered to the mailboxes of our 97,000
subscribers. Our goal is to help people choose the high-quality carbs
that are digested at a rate that our bodies can comfortably accommodate
and to share the latest scientific findings on food and diet with a
particular focus on carbohydrates, dietary fibres, blood glucose and the
glycemic index.
Publisher: Professor Jennie Brand-Miller, AM, PhD, FAIFST, FNSA
Editor: Philippa Sandall
Scientific Editor/Managing Editor: Alan Barclay, PhD, APD, AN
Contact GI News: glycemic.index@gmail.com
Sydney University Glycemic Index Research Service
Manager: Fiona Atkinson, PhD, APD, AN
Contact: sugirs.manager@sydney.edu.au
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5:07 am
FOOD FOR THOUGHT
FOOD, DIET AND HEALTH: HOW YOU CAN CHECK THE EVIDENCE
Low
carb diets. Low fat diets. Owning a dog. Eating leafy greens. Fermented
foods. Dairy foods. Eggs. Salt. Sugar. We are bombarded with conflicting
messages about food, diet and health in the media and on-line.
Universities and research organisations keen to promote their staff and
their findings in turn bombard the media with often inflated press
releases. How do we work out who or what to believe? In Food for
Thought, Dr Alan Barclay explains the different kinds of evidence and
how compelling it is, or isn’t.
THE STUDY: HOW COMPELLING IS THE EVIDENCE?
1. RANDOMISED CONTROLLED TRIALS (RCTS) ARE CONSIDERED THE “GOLD STANDARD”,
providing the highest level of evidence, as they can prove that
intervention A improves health outcome B, while all other known factors
(known as confounders such as age, gender, body mass index, etc.) have
been accounted for by the randomisation process. The process of studying
people tends to improve their health independent of the intervention
itself, because people know that they are being monitored and are more
conscious of their health, and are consequently being more careful about
what they eat and drink, so having a control group is vital. Only
randomised controlled trials are able to show that a particular
intervention causes a particular outcome.
2. OBSERVATIONAL STUDIES PROVIDE MEDIUM LEVEL EVIDENCE
because scientists are simply observing and measuring people’s
behaviour at a point in time, or over a particular time frame, without
randomising them to groups and providing different dietary
interventions. The best epidemiological evidence comes from large
prospective cohort studies where large groups (typically thousands) of
people have a medical check-up, their dietary patterns are measured, and
they are followed up regularly for long periods of time (e.g., 5–25
years).
Observational studies can’t provide as high a
level of evidence as RCTs can as it is not possible to control for all
confounders (e.g. people who are already overweight may drink more
beverages than those who aren’t, as fluid requirements are proportional
to body size, and being overweight is an independent risk factor for
developing many chronic diseases), and our tools of observation (e.g. a
food frequency questionnaire for measuring a person’s usual food and
drink intake) are imperfect. Observational studies are only able to
prove that event A is associated with outcome Z. It’s possible that
unknown or unmeasured intermediary factors (B, C, D, E, etc) are
involved. They are not able to prove that event A causes outcome Z –
only RCTs can.
3. ANIMAL STUDIES ONLY PROVIDE LOW LEVELS OF SCIENTIFIC EVIDENCE,
however, they can be used to generate hypotheses that can be tested in
human populations (either using RCTs or observational studies) and to
investigate hypothesised physiological mechanisms in experiments that
cannot be ethically conducted in people. They are also used to determine
the toxic dose of novel ingredients, like food additives, for example,
and results are extrapolated to people using a large safety factor
(typically 100 x).
HOW SCIENTISTS REVIEW EVIDENCE: 3 THINGS YOU NEED TO KNOW
1. SYSTEMATIC LITERATURE REVIEWS are based on careful searches of
scientific databases (e.g., PubMed, EMBASE, CINAHL, and Cochrane
Library) with pre-determined search terms looking for all of the
research published on a particular topic over a long period of time
(ideally with no time constraints). Once all studies have been
identified, researchers then go through each paper’s reference lists to
make sure as best as possible that they have not missed any additional
evidence. The data from each paper is then extracted and the results
summarised in a table. The quality of each study is also rated or
graded. Strong conclusions can be drawn from the summarised data.
2. META-ANALYSES
can be performed when three or more similarly designed studies on a
particular health outcome have been published in scientific journals.
The outcome data from each study is entered into specialised software
and weighted according to the study size and statistical significance. A
final summary statistic is given that indicates whether an intervention
is effective, and if so, how effective.
3. SYSTEMATIC LITERATURE REVIEWS AND META-ANALYSES OF RANDOMISED CONTROLLED TRIALS are considered the highest level of evidence. Cochrane reviews
are a good example of this method. You can also do systematic reviews
and meta-analyses of observational studies. However, because the
underlying study design is not as robust as the randomised controlled
trials, they are not considered to be as high a level of evidence as a
Cochrane review, for example.
WHAT DOES IT ALL MEAN?
If the latest study broadcast in the news is:
- A systematic literature review and meta-analysis of randomised controlled trials then the results are worth taking notice of if the people involved are similar to you, and live under similar circumstances.
- A systematic literature review and meta-analysis of observational studies then the results are interesting, but a randomised controlled trial in humans that studied the same effect would be necessary to prove that the relationship was causal.
- A systematic literature review and meta-analysis based on an animal study or in vitro (test-tube) study, then more research in people is needed to prove the hypothesis.
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WHAT’S NEW?
3 FIXES FOR A MEDIA DIET OF QUESTIONABLE SCIENCE
Will
leafy green vegetables prevent dementia? Or does living near heavy
traffic cause it? ConscienHealth’s Ted Kyle summarises John Ioannidis’
JAMA opinion piece describing our woeful current media diet of
questionable science and minor issues, while serious and substantial
health concerns get little attention.
1. FOCUS ON BIGGER ISSUES
Scientific articles are
getting more attention these days in the media. Ioannidis looked at the
top 100 papers ranked by how much media attention they received.
Altimetric scores were the measure. He found roughly half of the stories
dealt with health and lifestyle. But the focus was mostly on trivial
issues like coffee’s effect on lifespan. Even if it’s real, it’s not
really big. Pointless arguments about fats versus carbs are big too.
Ioannidis
says the answer is obvious. Focus on bigger issues, like tobacco and
obesity. Those subjects received relatively little attention, he said.
He did find one bright spot, though. Exercise is both important for
health and amply covered in the media.
2. FOCUS ON CLEAR RESULTS
Because
scientific controversies get so much attention, the public gets many
conflicting messages. For example, Ioannidis pointed to recent
controversial papers regarding red meat. Media attention, as measured by
Altimetric, went sky high on these studies.
This kind
of food fight is unhelpful, he writes: “Some expert advocates in these
fields have a large number of followers in social media that broadcast
their beliefs and attack opponents as being unethical, conflicted
individuals. Perhaps this behavior is based on good intentions (e.g., to
save lives), but heated advocacy is unsuitable for thoughtful,
disinterested scientific exchange. It seems more akin to religious
dedication to intolerant sects. Promoting such conflicts in the media
offers little public benefit.”
3. STOP HYPING OBSERVATIONAL FINDINGS
Most
of the high-scoring health and lifestyle articles were based on
observational research. What’s more, those observational studies attract
extreme news coverage. More so than randomized, controlled studies with
null results. In other words, once a supposition arises from a weak
observational study, even a well-controlled study might not kill it.
Ioannidis
says that observational research should be rare in high-impact journals
(like JAMA). Instead, they should appear mostly in journals for
specialized audiences, with appropriate caveats. Press releases for such
studies should fade away.
Sensation has always sold
newspapers. And today, it provides great clickbait. But serious health
journalists can do better. They would do well to pay attention to
Ioannidis.
Read more:
- ConscienHealth News
- Click here for the Ioannidis viewpoint in JAMA.
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